Endocrine Abstracts

BackgroundAdrenocortical carcinoma (ACC) is a rare disease with often poor prognosis. Previous research has shown that surgery in a Dutch Adrenal Network (DAN) center increases the chance of survival. We aim to explore the determinants and survival of patients with ACC recently treated in the Netherlands both within and outside DAN centers.MethodsWe analyzed retrospectively collected data from 172 adult patie...

Background: One in 5 million children is affected by adrenocortical carcinoma (ACC) each year. Since prognosis for children older than 4 years is limited, clinicians often choose aggressive treatment with etoposide, doxorubicin, cisplatin (EDP) and mitotane after resection. However, little is known about the impact of EDP-mitotane on development in children. We therefore aimed to provide an overview of side-effects and neurocognitive effects of EDP-mitotane in children.<p ...

Introduction: Pheochromocytoma, a rare catecholamine-secreting adrenal tumor, can cause hypertension and life-threatening complications. Hereditary cases have an increased risk of developing bilateral disease. Standard treatment involves radical adrenalectomy, leading to adrenal insufficiency in bilateral cases. Partial adrenalectomy aims to preserve adrenal function but has higher recurrence rates. This study compares outcomes of partial vs radical adrenalectomy in hereditary...